Phase III: Remodeling and Maturation
Occurs several weeks after injury.
Assembly and remodeling of the cellular matrix
Process can be delayed by certain medications including steroids and NSAIDS
Systemic Response
Natural Barriers
First Line of Defense
Inflammatory Process: Phase I
Reconstruction: Phase II
Proliferation and new tissue growth
3-4 days post Injury
Granulation tissue growth
MMPs breakdown extracellular matrix proteins
Angiogenesis factors
stimulate vascular endothelial buds growing
into wound
Fibroblasts stimulated by transforming growth factor-beta
Wound Healing
Second line of defense
Rapid Response
Subtopic
Conclusion of inflamation
Result of Tissue Injury
Epithelial barrier damaged
