cell injury

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myofibroblasts at damaged area

fibrous elements

smaller opening/skin stretched

new CT

cell injury

healing process

4. maturation

repair

maturation

reconstruction

collagen

crosslinking

type III to I

regeneration

original structure & function

3. proliferation

GFs

fibroblasts

granulation tissue components

tissue fibroblasts

elastin

fibronectin

glycosaminoglycans

collagen type III

damage to CT

epithelial cells

repithelialization

vertical differentiation

horizontal mitotic growth

vascularization

new blood supply

2. inflammation

immune cells

mast, dendritic, and other APCs

cascade by degranulating

leukoctyes to site

macrophages

arichidonic acid derivatives

prostaglandins

pain receptors

neutrophil chemotaxis

leukotrines

smooth muscle contraction

tumor necrosis factor alpha

proinflammatory effect

interferons

unwanted DNA/RNA replication

interleukins

immune response

platelet activating factors

leukocyte adhesion to endothelium

platelet aggregation

chemotactic factors

leukocytes to area of phagocytosis

capillary permeability

vasodilation

neutrophils

bacteria & debris

exudate to area & increase edema

vessel dilation & constriction factors

platelets

blood-clotting proteins

1. hemostasis

cytokines

keratinocytes

stored IL-1s

histamine

chemotactic factors

leukocyte infiltration

cytokines & GFs

vasodilation & capillary permeability

platelets come into contact with collagen

blood coagulation

intrinsic

Activated XII

Activated platelets

platelet phospholipids

extrinsic

tissue factor

Activated X

prothrombinase = common

prothrombin

thrombin

Activated XIII

fibrinogen

loose fibrin threads

strengthened fibrin threads

clot formed

activation and aggregation of platelets

vessel spasm/smooth muscle reaction

cell death