A lack of oxygen causes muscle pain and fatigue
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3
Jaundice
inflammatory response
Lack of oxygen in the brain
Digestion issues
Immune response
Malaria first infects liver cells.
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Destruction of red blood cells means lack of oxygen for muscle tissue
The inflammatory response occurs when toxins or foreign chemicals are found in the blood causing fluid to build up in the lungs
Increase in white blood cells affects part of the brain and causes the whole body to heat up
Excess fluid can cause breathing difficulties
Malaria infects red blood cells, causing them to become deformed and eventually burst.
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Liver damage causes the liver to secrete less enzymes which leads to digestion issues
Liver damage can cause toxins to build up in the blood
Lack of oxygen for the brain
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In some cases, the lack of healthy red blood cells causes anemia, which can cause the heart to beat irregularly
When red blood cells burst, they release a substance called bilirubin in the blood, causing the skin to turn yellow
Toxins and chemicals in the blood can damage the brain.
Malaria

Malaria

Digestive System

Digestive System

Liver

Stomach

Circulatory System

Circulatory System

Blood

Red blood cells

Heart

Causes

Mosquito bite

Malaria is transmitted by female Anopheles mosquitos. It enters the bloodstream when the mosquito sucks the blood of a human.

Symptoms

Fever

Vomiting

Headache

Muscle Pain

Nausea

Shortness of breath

Fatigue

Yellow Skin/eyes

Diagnosis

Blood sample

The blood of a patient can be examined under a microscope to determine if they have malaria or not. The parasite has a distinct shape which can be seen under a microscope.

Treatment

Drugs

Patients are given drugs such as quinine, to kill the parasite. However, this doesn't always work because the parasite has grown resistant to it over time.

Vaccine

Currently, there is no good vaccine that can provide full protection but, there is a vaccine that offers partial protection against some types of plasmodium.

Nervous System

Nervous System

Brain

Damage to the brain affects multiple systems at once

Immune System

Immune System

Fever

Respiratory System

Lungs

Integumentary System

Skin

Life Cycle of Plasmodium

Life Cycle of Plasmodium

Infected mosquito bites a human

When an infected mosquito drinks human blood for a blood meal, Plasmodium parasites in the saliva of a mosquito enter the human bloodstream.

Plasmodium sporozoites take shelter in liver cells, to avoid being recognized by the immune system.

Infects liver cells

Asexually reproduces in liver cells

Using the liver cells resources, the sporozoites asexually reproduce and create thousands of copies of itself.

Bursts out of liver cells and infects red blood cells

Once they are done developing into merozoites inside the liver, they burst out of the liver cells and use the cell membrane to avoid detection from the immune system. Once they enter the bloodstream, they start infecting red blood cells.

Asexually reproduce inside of red blood cells, while some parasites differentiate genders

The parasite uses the red blood cells to replicate itself, while some of the parasites develop into gametocytes, which can be either male or female.

Enters another mosquito when she bites a human with malaria

When another mosquito sucks the blood of an infected human, she ingests both male and female gametocytes, which sexually reproduce inside of the stomach.

Musculoskeletal system

Skeletal muscles