lymph

primary (central)

liver

bone maroow

prenatal

postnatal

thymus

structure

two lobs

devided by trabecules into lobules

cortex

cells

T lymphocyte

98%

phagocitosied by macrophages forming tingble body

2%

to medulla

macrophages

reticular cells

type 1

in the border of trabecules and capsule

ocloding junction

type 2

in the medle

dismosome junction

type 3

in the cortico-medullary junction

ocloding junction

APCs

MHC

medulla

cells

T lymohcytes only

reticular cells

type 4

cortico-medullary junction

ocloding junction

type 5

cytoreticolum

ocloding junction

type 6

in the middle (most common)

dismosome junction

30-40 gram

vascular supply

thymus artry

arterioles

cappilarry

vein

small bed

cortico-medullary junction

blood thymus barrier

prevents T lymphocytes to contact with blood-born macromolcule

type 1 reticular cells

medulla

cortex

function

primary organ for maturation

location

superior medisternum

encapsulated

dens C.T

thymic hormons

reticular cells !

paracrine hormon

types

thymusin

thymopiotine

thimlin

thymic humral facto

function

facilitate T lymphocyte proliferation

affected by

gonadal

somatotropine

petitury

thyroxine

suprarenal

adrenocorticosteroid

digourgi ssyndrom

failur in thymus devlopment

no T lymphocyte

infection

no Ca+

tetani

secondary (peripheral)

spleen

largest lymph organ

structure

capsulated

concave

helium

entry point

convex

pulp

white

central artry

cells

T lymphocyte

sorround central artry

B cells

frequently

push central artry to peripheral position

marginal zone

seprates white pulp from red pulp

interdegitation dendritic cells

cells

T lymphocytes

B cells

macrophages

functions

searching for antigenes

megration of B cells into white pulp

macrophages attack macro-organism

T lymphocyte activation

B cells activation

red

spongy

parts

splenic sinuses

endothelial cells (fusiform)

coated by basal lamina

discontineous

splenic cords

reticular fibers type 3

extravasted blood

satellet cells

to prevent coagulation of blood by isolating type 3 reticular fibers from the blood

macrophages

function

immutological

T lymphocyte proliferation

B cells proliferation

anti-bodies formation

hematological

destroing old erythrocytes

hemopiosis in fetal

storage of blood in animals

blood supply

splenic artry

trabecular artry

central artry

penicillary artrioles

sheathed artrioles

terminal artrioles

splenic sinus

venules

trabecular veins

splenic vein

portal vein

splenic cord

venules

lymph node

MALT

bone marrow

post natal