Classical receptors

Biochemical Reactions

por Jazmine Smith

Mind Map Assignment

por Lindsay Treppa

Teaching Process Phases

por TIFANY NAYELI YEPEZ PACHECO

Objective : Mensukeskan transformasi B2B dengan cara mempermudah transaksi digital dan connectivity, n transaction

por ibnu masud

I apologize, i had this done last week and just neglected to press submit, I will be on top of it for the rest of the quarter

Nuclear receptors

Types of nuclear receptors

Type 2

common receptor types

xenobiotic receptors

Activates drug metabolizing enzymes such as CYTP3A

Cholesterol receptors

Fatty acid receptors

form homodimers with Retinoid x receptor

primarily in nucleus

Hybrid

Examples

Vitamin D receptor

Thyroid hormone receptor

Form obligate heterodimers with RXR

Tyoe 1

primarily bind:

oestrogen, progesterone, androgen

Mineralocorticoids

Glucocorticoids

Form homodimers on ligand

Found in cytoplasm

Some of the slowest response times

Hours to days

Orphan receptors

Subtopic

Example

RXR receptor

No well defined ligand

Ligand examples

Vitamin D

many hormones

N terminal domain

Controls interactions with cofactors

C terminal domain

Governs nuclear localization

Ligand binding domain

DNA Recognition and binding domain

Major drug targets

Drug target exceptions

Drugs target nucleic acids

Antisense and siRNA targets

DNA/RNA metabolism

Drugs target other specific protiens

Signaling protiens

structural protiens

Transporters

Enzymes

ion channels

Main topic of lecture

Kinase linked receptors

Receptor examples

Cytokine receptors

Associate with Cytosolic tyrosine kinases

Serine/Threonine kinase

Transforming growth factor receptor

Receptor tyrosine kinases

Toll like receptors

Growth factor receptors

Ligand examples:

bacterial lipopolysaccharides

Cytokines

Growth factors

Insulin

Structure

Intracellular domain

Large extracellular binding site

Binding triggers dimerization of receptor

G-Protien Coupled receptors

Sesceptable to desensitization

Clinically, may need to increase dosage over time

Caused by excessive activation of GPCR

Occurs through phosphorylation of cytoplasm tail

May activate or inhibit effector protien

Alpha beta and Gamma subunit

Beta and Gamma subunits may bind targets

upon binding Alpha subunit converts GDP to GTP

Alpha subunit may continue affect effector protein randomly

GTP activates effector protien