PET Radiopharmaceuticals
F-18 FDG
Half life:
110 Min.
MOL:
Glucose analog. Metabolism. Passive diffusion
Uses:
Abnormal glucose metabolism
Oncology- Assessment of with suspected cancer.
Brain imaging- associated with foci of epileptic seizures.
Cardiac viability- CAD and L. ventricular dysfucntion.
F-18 Florbetaben(Neuraceq)
Half life:
110 Min.
MOL:
Binds to B-amyloid plaques in the brain. Crosses the BBB. Passive diffusion.
Uses:
Estimating B-amyloid plaque density in patients with cognitive decline. (Alzheimer’s).
F-18 Florbetapir(Amyvid)
Half life:
110 Min.
MOL:
Binds to B-amyloid plaques in the brain. Passive diffusion.
Uses:
Alzheimer’s & cognitive decline disorders. Estimate B-amyloid neurotic plaque.
F-18 Sodium Fluoride
Half Life:
110 Min.
MOL:
Accumulates in skeleton in an even fashion. Ion exchange.
Uses:
Skeletal imaging- Define areas of altered osteogenic activity.
F-18 Fluciclovine(Axumin)
Half Life:
110 Min.
MOL:
Amino acid transport across mammalian cell membranes.Taken up by prostate cancer cells.Active transport.
Uses:
Imaging in men for prostate cancer (based on PSA levels).
Rb-82 Chloride
Half-Life:
76 Sec.
MOL:
Analogous to Potassium (K+). Ion exchange.
Uses:
Myocardium rest and stress imaging and to evaluate for CAD.
N-13 Ammonia
Half life:
9.96 Min.
MOL:
Analog of ammonia. Distributed to all organs. Diffusion across capillary membrane, then metabolic conversion.
Uses:
Myocardium rest and stress imaging and evaluate for CAD.
Ga-68 Dotatate
Half life:
68 Min.
MOL:
Somatostatin receptor.
Uses:
Localization of somatostatinreceptor positive neuroendocrine tumors (NeTs)