Rhabdomyolysis

Increased uric acid concentration?

Compartment Syndrome

Crush injury

Lysis of skeletal muscle cells

Muscle swelling due to trauma

Compression of muscle due to inelastic fascia

Hyperkalemia

Myoglobin

Cardiac Arrhythmias

Release of intracellular contents into the bloodstream

Nucleotides

liver

increase of uric acid in kidneys

Buildup causes cast formation

Causes myoglobinuria

Filtered through kidneys

Distal tubular obstruction

Decrease in GFR

Low pH of urine

Half-isotonic saline with sodium bicarbonate

Hypovolemia

Allopurinol

Renal constriction

RAAS activation, SNS activation, ADH release

Fluid management

Monitor Labs

Strict I&Os

Acute tubular necrosis

Treat hypokalemia

Muscle Ischemia

Buildup of lactic acid

Myalgia and weakness

Mannitol

metabolic acidosis

Aggressively correct hypovolemia

Hypocalcemia

Hyperphosphatemia

Pharmacologic interventions

Non-pharmacologic interventions

Free radical formation

Renal ischemia