Wound Healing

Result of Tissue Injury

Epithelial barrier damaged

Conclusion of inflamation

Second line of defense

Rapid Response

Subtopic

Inflammatory Process: Phase I

Reconstruction: Phase II

Proliferation and new tissue growth
3-4 days post Injury

Fibroblasts stimulated by transforming growth factor-beta

Angiogenesis factors

stimulate vascular endothelial buds growing
into wound

Granulation tissue growth
MMPs breakdown extracellular matrix proteins

Systemic Response

Natural Barriers

First Line of Defense

Phase III: Remodeling and Maturation

Occurs several weeks after injury.

Assembly and remodeling of the cellular matrix

Process can be delayed by certain medications including steroids and NSAIDS