Progressive Supranuclear Palsy (PSP)

Progressive Supranuclear Palsy (PSP) is a rare and debilitating neurodegenerative disorder. Although the exact cause is unknown, it involves the misfolding of tau proteins. PSP is characterized by symptoms such as balance impairment, difficulty walking, abnormal eye movements, muscle tone issues, speech problems, and swallowing difficulties.

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Progressive Supranuclear Palsy (PSP)

Current Research

There has not been many breakthroughs with PSP research but this site compiles all the latest information about PSP research.

How can I help?

Cure PSP is a nonprofit foundation working to improve awareness, education, care and cure for devastating prime of life neurodegenerative diseases. (About CurePSP - CurePSP, 2020)

Related Feature and Symptoms

Many of the traits that can identify PSP are very common amongst degenerative neurological disorders. But there are a few signs that can help identify PSP. - Lack of shacking - Poor/No response to Parkinson's medication - Difficulty moving eyes, particularly downwards

What is the cause?

The cause of PSP is unknown, but they know the PSP is a form of heterogenous group of neurodegenerative diseases characterized by abnormal tau proteins misfolding

Subtopic

History

In 1877 Dr. Charcot described a woman with some traits of PSP In 1951 Chavany reported a man with similar traits to the woman PSP was first described as a distinct disorder by neurologists John Steele, John Richardson, and Jerzy Olszewski in 1963. In 1963 PSP was considered a new disease because there were only 22 well reported cases.

Treatment/Prevention

There is no cure to PSP, but some medication may provide the patient with short lasting relief. - Antiparkinsonian agents -Levodopa (May help with slowness, stiffness, and balance) -Ropinirole -Botulinum Injections (May help with excessive eye closing) -Antidepressants (May help with pain relief and decrease drooling)

What is PSP?

Progressive Supranuclear Palsy is a rare degenerative neurological disorder that can cause impairment to: - Balance - Walking - Eye Movement - Abnormal muscle tone - speech difficulties - Swallowing

Photo of my grandfather before PSP and during (Before) Black and white photo (After) Coloured photo

(I thought it would be interesting for me to put some personal experience in here but you don't have to read this) My grandfather was diagnosed with PSP right around the year I was born(2004), the life expectancy for someone with PSP is 6-7 years he died when I was about to turn 5 (2009). Since he died when I was very young I can't really remember him. He lost his speech by the time I could really remember him, I've never heard his voice before. He would cry a lot and it wasn't because he was sad its just what would happen. We would visit him every holiday and give him a little plushy these are the best memories I have of him. Seeing someone detartrate mentally like this is probably one of the hardest things I've ever had to watch. In the grand scheme of things its only been 16 years since he was diagnosed but it saddens me that there really has been no progress to at least help with the pain.