THE ROLE OF THE GUT MICROBIOME IN MENTAL HEALTH
Increased serotonin at the synapse
EXTRAPYRAMIDAL MOVEMENT SYMPTOMS
Serotonin

Serotonin

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STRUCTURE:A monoamine neurotransmitter derived from tryptophan#**add structure/ SAR hereFUNCTION:-         play a role in regulation of mood, sleep and cognition and memory

Depression

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Pathophysiology of Depression- The role of serotonin

The patient's experience: Counselling points - Starting SSRIs = two week lead time for a notable improvement

Drugs which target serotonin

SSNRI

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dual selectivity for serotonin/norepinephrineduloxetinevenlafaxinemilnacipran

SSRIs

Chemistry: The delayed therapeutic effect

examples of SSRIs

Mechanism: SSRIs block SERT Transporters to increase serotonin in the synapse

MAOI

MECHANISM: increase serotonin, but also increase DOPAMINE at the synapse

Parkinson's disease

The Enteric Nervous System

Release of Serotonin in response to Cholera toxin

Schizophrenia

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PATHYPHYSIOLOGY OF SCHIZOPHRENIA: the serotonin hypothesis-         The DOPAMINE hypothesis -          The SEROTONIN hypothesis-         The GLUTAMATE hypothesis -         The CANNABINOID hypothesisThe Serotonin hypothesis in schizophrenia attributes the negative symptoms of the disease to an overload of serotonin. These increased levels of serotonin reduce dopamine transmission in the forebrain, which is thought to cause negative symptoms.Atypical neuroleptics target these negative symptoms by blocking this extra serotonin.

Treated with DOPAMINE ANTAGONISTS

Serotonin signalling