Hypothalamus
Makes CRH
Anterior Pituitary
Make ACTH
Adrenal Cortex
Makes adrenocortical agents
Androgens
testosterone
present in
males & females
Glucocorticoids
Use: Short-term antiinflam. tx.
increase glucose levels
increase protein breakdown
decrease protein formation
decrease inflammation
suppress immune system
Drugs: end in -sone, -olone
cortisone
hydrocortisone
methylprednisolone
prednisone
Mineralcorticoids
Use: adrenal insuff. relace. tx.
increase Na+ retention
increase water retention
decrease K+ levels
Drugs: most have glucocorticoid prop.
cortisone
fludrocortisone
hydrocortisone