Types of Immunity
Innate Immunity
Invariant
Types of Invariant Immunity
Skin
Mucous
Antimicrobials/Enzymes
Histatin
Defensins
Lysozymes
WBC
Monocytes
Natural Killer Cells
Granulocytes
-phils
Mast Cells
Dendritic Cells
Functions of Invariant Immunity
Be part of the 1st and 2nd lines of defense against
pathogens that can invade the human body
Induced
Types of Induced Immunity
Inflammation
Pain
Redness
Swelling
Heat
Complement
Antibody Dependent
Classical Pathway
An-Abo Complexes on pathogen surfaces
C1q, C1r, C1s
C4
C2
Antibody Independent
Lectin Pathway
Mannose-binding lactin binds to the
mannose on pathogen surfaces
MBL, MASP-1, MASP-2
C4
C2
C3 Convertase
C3a, C5a
Peptide mediators of inflammation,
phagocyte recruitment
C3b
Binds to complement receptors on phagocytes
Opsonization of pathogens and
removal of immune complexes
Terminal complement components
C5b
C6
C7
C8
C9
MAC, lysis of certain pathogens and cells
Alternative Pathway
Pathogen surfaces
C3
B
D
Functions of Induced Immunity
Take on a more active role in defeating pathogens
Chemicals Secreated
Complement
Enzymes and Antimicrobials
Cytokines and Chemokines
Adaptive Immunity
T Cells
Types of T Cells
Helper T
Cytotoxic T
Memory T
Regulatory
Functions of T Cells
Assist other white blood cells in immunological maturation (i.e. B cells into plasma and memory B cells)
Activate cytotoxic T cells and macrophages
Destroy virally infected cells through CD8 and MHC-I
Maintains immunological tolerance - not attacking self cells
Origin/Activation of T Cells
Originates in the bone marrow
In order to develop into mature T-Cells the immature must travel to the thymus
B Cells
Types of B Cells
Plasma B
Memory B
Functions of B Cells
Make antibodies against antigens, thereby performing as an Antigen-Presenting Cell (APCs)
Develop memory cells that can be used in future infections
Origin/Activation of B Cells
Originates also in the bone marrow
Stays in the bone marrow to mature