Multiplication of Animal Viruses

attachment sites are distributes all over virus

adenovirus--icosahedral--small fibers at corners

enveloped--influenza--spikes

receptor sites are inherited characteristics of the host

receptor forparticular virus varies from person to person

by pinocytosis

enveloped viruses can enter by fusion: envelope fuses with PM and releases capsid into cell's cytoplasm

HIV

separation of viral nucleic acid from it's protein coat once the virion is enclosed w/in vesicle

poliovirus--uncoating starts to happen while virus is still attached to PM

Herpesviruses

papoviruses

Adenoviruses

Hepadnaviruses

1-2. viral DNA released into the nucleus of host cell

3. transcription of viral DNA...translation..

4. transcription and translation of "late" viral genes...capsid and structural proteins

5. synthesis of capsid proteins in cytoplasm

6. maturation...assembles to form complete viruses

7. released from host cell

DNA Viruses

Adenoviridae: common cold

Poxviridae: skin lesions--cow pox and smallpox

Herpesviridae: spreading appearnce of cold sores

Simplexvirus: cause cold sores

Varicellovirus: chickenpox

Lymphocryptovirus: infectious mono

Cytomegalovirus: CMV Inclusion Disease

Roseolovirus: Roseola

Kaposi's sarcoma, primarily in AIDS patients

Papovaviridae

name from papillomas (warts), polomas (tumors) and vacuolation

some Papillomavirus can ause cancer

Hepadnaviridae

cause hepatitis and contain DNA

synthesize DNA by copying RNA using viral reverse transcriptase

multiply in host cell's cytoplasm

Picornaviridae

poliovirus

single-stranded RNA

smallest viruses

RNA w/in virion is callsed sense strand because it can act as mRNA

new strand is antisense strand

contain RNA dependent RNA polymerase

Togaviridae

arthropodborne, arboviruses or alphaviruses

contain singe sense strand of RNA

enveloped

Rhabdoviridae

rabiesvirus

bullet-shaped

single antisense strand of RNA

contain RNA dependent RNA polymerase

Reoviridae

respiratory and enteric systems

double stranded RNA

contain RNA dependent RNA polymerase

Retroviridae

infect vertebrates

Lentivirus

carry reverse transcriptase which uses viral RNA as template and degrades original viral RNA

integrated into host cell chromosome as a provirus which gives it protection from antivieral drugs

in oncogenic retroviruses the provirus can convert host cell into a tumor

starts with assembly of protein capsid

envelope develops around capsid by budding

capsid pushes through PM..buds...cell usually doesn't die

nonenveloped released thru ruptures in OM...leads to cell death