SSTI

Non-purulent

Mild

PO Antibiotics

Pyogenes

PCN, Cephalexin, Clindamycin

MRSA?

+ Bactrim, Doxy

Moderate/Severe

IV Antibiotics

Pyogenes

PCN, Cefazolin, Clindamycin, Ceftriaxone

Necrotizing fascitis? (Type II)

Debridement

PCN + Clindamycin

MRSA?

Vanc, Dapto, Linezolid

Necrotizing fasciitis? (Type I)

Debridement

+ Pip/Tazo, Imi/Cilast, Meropenem

Purulent

I/D

Mild

No Meds

Moderate

PO Antibiotics

MRSA

Bactrim, Doxy

Severe

IV Antibiotics

MRSA

Vanc, Dapto, Linezolid