Drug Targets (4)

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Macromolecules

Szerző: Hannah Joy

S2016 Final Concept Map

Szerző: Pamela Harvey

Final Concept Map

Szerző: Adanna Onyeka

Denaturation of DNA

Szerző: Simmi Sekhon

Drug Targets (4)

4) Transporters

3) Enzymes

2) Ion Channels

1) Classical Receptors

III. Kinase-Linked Receptors

Cytokine Receptors -Associate with JAK

Serine/Threonine Kinases -Transforming Growth Factor Receptor

RTKs -receptors for growth factors like EGF, NGF and toll-like receptors

IV. Nuclear Receptors

CLASS 2

Hybrid Class

CLASS 1

II. GPCRs

Isoforms of G protein

G q

Upon ligand binding, 'G alpha Q' dissociates and GDP-> GTP. Activates Phospholipase which then converts PIP3 (in membrane) to IP3 and DAG. DAG activates PKC which goes on to phosphorylate substrates. IP3 travels across the cytosol to the ER where it binds to Ca2+ channels to allow for the outpour of Ca2+ into the cytosol.

G alpha i

Upon ligand binding, 'G alpha I' protein dissociates from complex and GDP -> GTP. The protein then inhibits AC so that no cAMP is produced, and thus PKA remains inactive.

G alpha s

Upon ligand binding, 'G alpha s' protein dissociates from complex and GDP-> GTP. Activates AC. AC converts ATP to cAMP which goes on to activate PKA.

c. Metabotropic Glutamate Receptor/ Ca Sensor Family

b. Secretin/Glucagon Family

a. Rhodopsin Family

I. Ligand Gates Ion Channels