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Hemostasis

The discussion encompasses various medical treatments and interventions related to blood clotting and its management. It distinguishes between arterial and venous conditions and outlines different classes of medications, including antiplatelets, anticoagulants, and thrombolytics.

Hemostasis

Hemostasis

Venous

Anti-coagulants
Rivaroxaban

Factor Xa antagonist

Heparin

LMW (Enoxaparin)

Synthetic heparin (Fondaparinux)

Immune thrombocytopenia

ATIII

Protamine sulfate (unfrac.)

PTT

Warfarin

Subtopic

Necrotic skin ulcers

Hematuria

GI bleed

Pregnancy

Antidotes

Fresh frozen Plasma

Vitamin K

PT

Arterial

Acute
Thrombolytics

Antidote

Aminocaproic acid

Nonselective

Urokinase

Streptokinase

Beta-hemolytic strep

Loading dose saturates Ab

Selective

Antistreplase

tPA

$$$

Anti-platelet
Ticlopidine

TIA/Stroke

Clopidogrel

More efficacious than ASA

Long-term

TTP

ASA

PO

Blocks COX

No TXA2

Long-term prevention

IIb/IIIa Inhibitors

IV

Rapid onset

Bleeding

PCI/ACS

Eptifibatide

Abciximab