ANEMIA of CHRONIC INFLAMMATION
Systemic Inflammation
Auto Immune diseases, Infections, Malignancies, Burns, Trauma
Increased Cytokine production
Decrease RBC productio
Increased RBC Destrucion
Decrease Iron availability
Spleen
Iron stored as Ferritin
Bone Marrow
Pluripoint stem cells
Proerythroblasts
Multiple divisions
accumulates Hemoglobin
Nucleus lost
Loses mitochondria and ribosomes
Reticulocytes released into circulatory system
Mature Red Blood Cells
Liver
Iron stored as Ferritin
Brenda Mitchell
DIAGNOSTIC LABS
CBC - low RBCs
Low serum iron
Decreased Transferrin saturation