optic atrophy

visual dysfunction (vision and/or visual field loss)

Based on the findings of disc pallor associated changes in the integrity of the retinal nerve fiber layer and retinal vessels

Bilateral unexplained visual loss

Thinning of retinal nerve fiber

Molecular diagnosis by identification of a mutation in the OPA1 gene or in the OPA3 gene.

Glaucoma

Stroke of the optic nerve

Tumor

hereditary condition

Blurred vision

Abnormal side vision

Abnormal color vision

Widening of the pial septa

Shrinkage or loss of both myelin and axis cylinders

Gliosis

Widening of the subarachnoid space with redundant dura

-38 Years old male African American

Symptoms: Blurred vision, flashes of light, floaters

BCVA  OU 20/200

-Prevalence of blindness attributable to optic atrophy was 0.8%.

Race:Optic atrophy is more prevalent in African Americans (0.3%) than in whites (0.05%).

Age: Optic atrophy is seen in any age group.

Lenaers et al.: Dominant optic atrophy. Orphanet Journal of Rare Diseases 2012 7:46.

Osaguona VB, Okeigbemen VW. Nonglaucomatous optic atrophy in Benin City. Ann Afr Med 2015;14:109-13.

Aijaz S, Erskine L, Jeffery G, Bhattacharya SS & Votruba M (2004): Developmental expression pro- file of the optic atrophy gene product: OPA1 is not localized exclusively in the mammalian retinal ganglion cell layer. Invest Ophthalmol Vis Sci 45: 1667–1673.