Drug Administration

Disintegration and Dissolution

Absorption

Surface Area

Blood Flow

Concentration

Acid-Base Properties

Lipophilicity

Compatibilty

Distribution

BARRIERS

Factors

Cardiac Output

Regional Blood Flow

Drug Reservoirs

Plasma

Fat Tissue

Bone Tissue

Blood-Brain Barrier

Placental Barrier

Metabolism (Biotransformation)

Liver

Oxidation, Hydrolysis, or Reduction

Conjugation

Plasma

Kidneys

Lungs

Intestinal Mucosa

Solid

Tablets

Compressed

Sugar coated

Film coated

Enteric coated

Multiple Compressed

Controlled release

Effervescent

Buccal (Sublingual)

Capsules

Hard Gelatin

Soft Gelatin

Troches

Lozenge

Pastille

Suppositories (Inserts)

Rectal

Vaginal

Liquid

Solution

Emulsion

Suspension

Gas

Ex: Oxygen, Anesthesia, Aerosol Inhalers