Myocardial Performance

Contractility

Digoxin

Preload

Diuretics

Nitrates

Acute angina

Nitroglycerin

Almost every route

Dx Use

Amyl nitrate

Inhalation

Malignant HTN

Nitroprusside

Thiocyanate

B12

Reduces toxicity

Angina prophylaxis

Isosorbid dinitrate

Headache

Flushing, Burning

Hypotension

Other

Morphine

Think PBL case

Heart Rate

Goal of TherapyDecrease HR --> Increase filling time --> Increase cardiac output

Beta-blockers

Calcium channel blockers

Digoxin

↑Vagal tone

Afterload

Alpha-1-blockers

Prazosin

Doxazosin

Long-acting

Lipid Profile

↑ HDL

↓LDL

Terazosin

1st-pass Syncope

Calcium-channel blockers

Verapamil

Diltiazem

Cardiosparing

Nifedipine

Headache

Facial flushing

Edema

GI Problems

Arterial relaxants

Diazoxide

Hyperglycemia

Hydralazine

Lupus-like syndrome

Minoxidil

Hypertrichosis

Pinacil

Always use w/ BB + Diuretic

You need to block the compensatory effects of the baroreceptor reflex.

Diuretics

PDE5 Inhibitors

Sildenafil (Viagra)

Subtopic

Vardenafil (Levitra)

V = Very quick onset

Tadalafil (Cialis)

(36h)

↑cGMP

Pulmonary HTN

Nitrates

Priapism

Does your erection last for more than 4 hours?

Cardiac Remodeling Prevention

Aldosterone antagonists

Renin antagonist

Aliskiren

ACE inhibitors

Captopril

Dry cough

Kidney-sparing

Pregnancy

ARBs

Blocks locally produced AgII

Pregnancy

Beta-blockers

Carvedilol

Labetalol