によって Felicia MedStudent 16年前.
452
Gout Treatment
Gout is a condition characterized by the formation of uric acid crystals, particularly in joints like the big toe. These crystals trigger an immune response, leading to inflammation and discomfort.
によって Felicia MedStudent 16年前.
452
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dz produced by the formation of uric acid crystals (tophi) in joints (b/c there's low fluid there), especially in the big toe
the crystals provoke an immune response
granulocytes respond and their high metabolic activity produces lactic acid, reducing pH and causing more uric acid to precipitate
MOA same as probenecid
hypersensitivity not common
GI side effects
other uses:
antithrombic (like aspirin)
@ high doses, inhibits secretion + reabsorbtion
(what we want in a gout treatment -- whatever's in there just passes right thru)
@ low doses, inhibits secretion not reabsorbtion
drug must be in filtrate to act on transporters on the apical surface
complications
it antagonizes diuretics
aspirin prevents its action
predisposes to kidney stone
GI disurbances
other uses
uncomplicated gonoccocal infxn
MOA: inhibits xanthine oxidase
Contraindications
acute gouty attack
may worsen an acute gouty attack if used as 1st tx
MOA: inhibits activities of leukocytes (esp. granulocytes)
AE:
severe n/v, limits effectiveness
