Hemostasis
Venous
Anti-coagulants
Rivaroxaban
Factor Xa antagonist
Heparin
LMW (Enoxaparin)
Synthetic heparin (Fondaparinux)
Immune thrombocytopenia
ATIII
Protamine sulfate (unfrac.)
PTT
Warfarin
Subtopic
Necrotic skin ulcers
Hematuria
GI bleed
Pregnancy
Antidotes
Fresh frozen Plasma
Vitamin K
PT
Arterial
Acute
Thrombolytics
Antidote
Aminocaproic acid
Nonselective
Urokinase
Streptokinase
Beta-hemolytic strep
Loading dose saturates Ab
Selective
Antistreplase
tPA
$$$
Anti-platelet
Ticlopidine
TIA/Stroke
Clopidogrel
More efficacious than ASA
Long-term
TTP
ASA
PO
Blocks COX
No TXA2
Long-term prevention
IIb/IIIa Inhibitors
IV
Rapid onset
Bleeding
PCI/ACS
Eptifibatide
Abciximab
