coag
thrombocytosis
splenectomy
myeloproliferation
excitement/EPI
inflammation
Fe deficiency anemia
hypercoagulability
nephritic syndrome
vascular abnormalities
Marfan
Ehlers Danlos
collagen disorders
Cushings
scurvy
endothelial injury
coagulopathy (hemorrhage)
factors
common (X, V, II, I)
ACT
PT
extrinsic (TF -> VII)
PT (-75%)
vit K antagonism
intrinsic (XII, XI, IX, VIII)
ACT (-95%)
PTT (-75%)
haemophiliacs
autoimmune dz
amyloidosis
- X lost to matrix
severe liver dz
+ FDP (not filtered out)
vit K antagonists
multifactorial
any other factor (sauf XII)
von Willebrand (vWF)
hemophilia A (VIII)
PTT
thrombopathy (petechiae)
thrombocytopathy
hereditary
thrombopathies
thrombasthenias
vWF
acquired
uremic plasma waste products
phenothiazine tranquilizers
autoimmune
FDPs
abnormal plasma proteins
NSAIDs
thrombocytes > 10-50k
BMBT
thrombocytopenia
sepsis (LA)
+ sequestration
splenomegaly
+ destruction
ehrlichiosis
iatrogenic heparin
ITP (ca)
+ consumption
vasculitis
hemangiosarcoma
DIC
- ATIII
schistocytes
+ D dimers
+ FDP
- fibrinogen
- then + PTT, PT
- production
macroplatelets
regenerative
± BMBT
thrombocytes < 10-50k
