Biological Macromolecules

Proteins

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-a large molecule consisting of many amino acid subunits -joined by peptide bonds and folded into a specific three-dimensional shape

Amino Acids

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-is a molecule containing a carboxyl group, an amino group and a side group (R group)-the difference in R groups is what distinguishes amino acids from each other-there are 20 different amino acids (meaning 20 different R groups)

Primary Structure

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-unique linear sequence of amino acids in each polypeptide chain-20^2= 400 combinations of two amino acids-20^20 ..... virtually limitless number of combinations

Secondary Structure

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-hydrogen bonding between different parts of the amino acid backbone creates two common secondary structures

Alpha Helix

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-in an a helix, the carbonyl of one amino acid is hydrogen bonded to the amino H (N-H) of an amino acid that has four down the chain-coiled structure in filamentous and transmembrane proteins

Tertiary Structure

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-3 dimensional shape due to intermolecular reactions between R- groups

Quaternary Structure

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-many proteins are composed of two or more polypeptides joined together -held together by the same types of bonds as in the tertiary structure

Beta Sheet

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-two or more segements of a polypeptide chain line up next to each other-forming a sheet-like structure held together by hydrogen bonds

Nucleic Acids

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-are the assembly instructions for all proteins in living organisms

Nucleotides

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-are the buiding blocks of nucleic acids-are liked together by a sinlge bridging phosphate group between the 5'-carbon of one sugar and the 3' -carbon of the next sugar

Nitragenous Base

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-an organic molecule with a nitrogen atom that has the chemical properties of a base-bonds nucleic acids together

ACGTU

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-the nitrogenous bases in DNA are adenine (A), guanine (G), thymine (T), and cytosine (C)-the nitrogenous bases in RNA are adenine (A), guanine (G), uracil (U), and cytosine (C)

ATP

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-is a molecule that carries energy within the cells-referred to energy currency of the cell

Pentose Sugar

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-is a monosaccharide ("simple" sugar)-has five carbon atoms

Ribose

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-found in RNA-is a "normal" sugar, with one oxygen atom attached to each carbon atom

Deoxyribose

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-found in DNA-molecules bound to both a phosphate group and either a purine or a pyrimidine-helps form the backbone of DNA molecules

Phosphate Group

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-a molecule containing one atom of phosphorus covalently bound to four oxygen residues -relatively reactive molecules that form phophoester fonds by the interaction with hydroxyl groups

DNA

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-sugar-phosphate backbone-5' end has phosphate, 3' end has the sugar -four bases projecting from the backbone (A,T,C,G)-double-stranded-strands run antiparallel to each other-hydrogrn bonds form between complimentary bases on opposite strands (G forms 3 bonds with C, and A forms 2 bonds with T)-twists into double-helical formation

RNA

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-sugar-phosphate backbone-4 bases (G,C,A,U)-single-stranded

Carbohydrates

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-a molecule that consists of carbon, oxygen, and hydrogen

Monosaccharides

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-the simplest form of a carbonhydrate

Glucose

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-is a monosaccharide containing six carbon atoms -found in fruits and plants

Fructose

Galactose

Disaccharides

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-two monosaccharides joined by a dehydration synthesis reaction

Sucrose

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-a molecule composed of two monosaccharides-produced natuarlly in plants -common sugar

Lactose

Maltose

Oligosaccharides

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-two or more monosaccharides join together by O-glycosidic bonds

Raffinose

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-composed of galactose, glucose, and fructose-can be found in vegetables and whole grains

Stachyose

Polysaccharides

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-a molecule that contains many linked monosaccharides -large source of energy

Cellulose

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-is a molecule consisting of hundreds of carbon, hydrogen and oxygen atoms-main substance in the walls of plant cells-important in a humans diet as fibre

Starch

Glycogen

Lipids

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-a nonpolar compound that is made mostly of carbon and hydrogen

Phospholipids

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-a lipid that contains two fatty acid chains and a phosphate group bound to a glycerol-polar, hydrophilic head-nonpolar, hydrophobic tail-the primary lipid of a cell membrane

2 Fatty Acids

Diacylglycerol

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-consists of two fatty acid chains covalently bonded to a glycerol molecule through ester linkages-2 possible forms exist, 1,2-diacylglycerols and 1,3-diacylglycerols

Fats

3 Fatty Acids

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-a hydrocarbon chain with a carboxyl functional group

Saturated

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-only single bonds in the hydrocarbon chains-tend to be solid at room temperature and from animal sourcs

Unsaturated

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-double bonds in the hydrocarbon chains-are usually liquid and from plant sources

Glycerol

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-it has 3 carbon atoms, 8 hydrogen atoms, and 3 oxygen atoms-the chemical structure of glycerol shows that each carbon atom is bonded to an -OH group

Triglycerol

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-large source of energy, but more difficult to utilize than carbohydrates-3 fatty acids linked to a glycerol molecule

Steriods

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-a lipid composed of four carbon rings

Cholesterol

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-plays an important role in your body-needs it to make hormones, Vitamin D and help aid in digestion

Hormones