Alterations of Leukocytes - Copy

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Leukemia

abnormal blast wbc overcrowd bone marrow and spill into blood

overcrowding causes normal cells to cease functioning

Leads to PANCYTOPENIA

Lymphoctosis

Basopenia

shift-to-the-left

Increased amount of immature neutrophils released into circulation cause a shift to the left. This can be due to either an infectious process, and the body is unable to keep up with production of neutrophils, or from leukemia as well.

Myelocytic Leukemia can cause neutrophilia

Neutrophil count > 100,000, raises blood viscosity significantly increasing chance for thrombosis or complete occlusion of blood vessels.

Decreased circulating granulocytes exhausted by an ongoing infection

Neutropenia

Severe neutropenia, <500, is usually d/t issues with production in bone marrow

typically resultant from chemotherapy or other malignancies.

Increased risk for infection

Increased number of circulating granulocytes

An increased number of granulocytes is a primary response to an infectious process. However, myeloproliferative disorders such as leukemia can also cause an increase.

Quantative or Qualitative disorder?

Disorders of the white blood cells resulting in levels too low or too high are quantitative, whereas qualitative disorders describe problems with the function of the cell.

Alterations of Leukocytes

Causes?

Cancerous pathophysiology

Infectious Process