RS HSP mindomo assignment

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Henoch-Schönlein Purpura

Health Promotions

General health and hygiene recommendations suggested to reduce incidence of viruses that may cause the abnormal immune response seen in HSP.

There is no known way to prevent HSP

Treatment

Glucocorticoids - low dose and tapered slowly if used. Skin lesions and kidney disease do not response to corticosteroids alone. Cyclosporine may be beneficial to add.

Supportive care: hydration, rest, pain relief

Majority of cases will resolve spontaneously

Symptoms

Skin rash or urticaria

Joint pain or swelling (mainly knees and ankles)

Abdominal pain/vomiting

Hematuria, proteinuria

Signs

GI bleeding or vomiting (potentially intussusception)

Nephropathy (hematuria, RBC casts, proteinuria, slightly elevated CK)

Arthritis (nondestructive)

Palpable purpuric skin lesions (typically appears in crops)

Pathophysiology

IgA immune mediated vasculitis of unknown etiology

Genetics

Not inheritable

Genetic predisposition may be associated with HLA-DRB1*01 allele

Epidemiology

Male > Female

Most common form of vasculitis in children

Etiology

May be triggered by URI, chickenpox, strep throat, medications, food, or exposure to cold weather.

Unknown