Lowering BP

Mais informações

Blood pressure elevated

por Lauren Cagle

STAGES OF VIRAL INFECTION INHIBITORS

por OBENEFIRO ABU

Diuretic Renal Imaging

por alyssa lopez

ACE inhibitor

por Damian Guzman

Lowering Blood Pressure

also std of care for diabetic nehpropathy

reduce AT II action

ARB's (AT Receptor Blockers)

Valsartan

MOA: blocks binding of AT II to AT-1 receptors (same as losartan K)

food markedly decreases absorbtion

Diovan HCT

Losartan Potassium

MOA: blocks binding of AT II to AT-1 receptors

*more efficacious in reducing the action of AT II

actions:

available in combo with HCTZ

Hyzaar

NO COUGH!

dizziness

decrease AT II production

PDP/ACE Inhibitors

Use for:

- esp diabetic nephropathy <--ACE or ARB

all are renal sparing, so they do not increase transglomerular pressure

Lisinopril

advantages

Enalapril

MOA: same as captopril

advantages:

bioavailability not affected by food

qd dosing

IV admin

No sulfhydryl group so fewer AEs

has carboxyl group instead

AE

no hypogustia

Captopril

MOA: blocks conversion of AT I -> AT II and increases activity of bradykinin (which breaks down vasodilators to inactive peptides)

(1) decreases production of vasoconstrictors (AT II)

(2) decreases destruction of vasodilators (bradykinin)

renal sparing

does not increase transglomerular pressure

which would lead to glomerular damage

drug interactions

w/ triamterene or amiloride

AE:

increased renin and AT I production

hypoglycemia

rash (hypersensitivity)

neutropenia

proteinuria

non-productive cough

b/c increased bradykinin stimulates the cough reflex

hypogustia (loss of taste)

hyperkalemia

Mineralocorticoids

K-sparing diuretics

Physiologic Antagonists

Amiloride

Triamterene

Competitive Antagonists

Eplerenone

much more specific mineralocorticoid antag

Spironolactone

binds to mineralocorticoids, androgen, AND progestin receptors

Agonists

in combo with glucocorticoids, are used as replacement in adrenal insufficiency

Deoxycorticosterone acetate (DOCA)

IV or IM in oil

Fludrocortisone

DoC, oral

Decrease Renin

decrease renin release

CNS Adrenolytics

eg. Clonidine, Methyldopa

Beta Blockers

eg, Propranolol

inhibit renin action

Aliskiren (Tekturna)

renin inhibitor