Summary on NAR database

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The 2013 NAR database issue and online molecular biology database collection

How are the NAR databases being organised?

Reason of databases are created and shared

a) Better understanding of the genomic data which allows biomedical experts use it to treat human disease.

b) Easy way to access and cross reference between different databases

c) Consistent improvement of existing databases

d) Partnership allows handful of data for exchange which leads to wide coverage and effortless data management

Criteria for selection

a) Database has large scope of coverage

b) Offers guarded first hand data together with user friendly search tools

c) Focus is on the usefulness of the database for NAR users

d) "Boutique" databases will be selected if the topics covered are of general interest

e) Open for submissions from good review and established databases in future

f) Paper submitted was not published elsewhere unless under special conditions

g) Only update papers from most popular databases are accepted. Other databases require significant new developments to be qualified for publication

Reason of some databases are not longer in the databases and dropped from it

a) Unresponsive and outdated websites

b) Budget constraints. Eg. ExDom database charges its users

c) Replaced by more updated and encyclopedic databases

d) Overlapped with other publication

Reason of grouping databases

d) Databases under the same topic allows comparisons and deciding on the more reliable predictions

c) Provide relevant information for research on disease fighting particularly for cancer

eg: UCSC Cancer Genome Browser, Atlas of Genetics and Cytogenetics in Oncology and Haematology and the TP53 website

b) Provide a better understanding of eukaryotic repeat elements

eg: Dfam and SINEBase

a) Able to retrieve related information in shorter time

Number available

1512 online databases up to date, sorted into 15 categories and 41 subcategories

Timeline for database development

In year 2013,emphasis of databases are on:

i) Mechanisms of protein–ligand binding

ii) Basis of human disease, potential drugs and their targets

iii) Genomic and RNAseq data for monkeys (comparative genomics purpose)

Availability of genome data enables research on improving human health.

In year 2012, main highlight of databases were:

i) Human proteins

ii) BioSample databases

iii) Principles of NCBI Taxonomy Database

iv) Gene Ontology and UniProt Gene Ontology Annotation projects

Trend observed was focused on small molecules and relevant topics.

On July 1, 1993, the NAR supplementary issue was officially named as the Database Issue. Total of 24 articles included:

i) ENZYME database

ii) RNA and protein structure databases

In April 1991, NAR had 18 articles whereas in May 1992, it had 19 articles. Types of articles in general:

i) Medical genetics database (Haemophilia B)

ii) Nucleotide sequence databases (GenBank, EMBL Data Library)

iii) Protein databases

Eg: SWISS-PROT, PIR, PROSITE, Restriction Enzyme Database (REBASE), Transcription Factors Database (TFD) and Histone database

In 20th annual Database Issue (2013), 176 articles included.

88 new online databases

77 update articles on databases formerly covered in NAR Database Issue

11 update articles that have been previously presented in other journals

Major database categories

Human and other Vertebrate Genomes

Human Genes and Diseases

Proteomics Resources

Organelle databases

Plant databases

Cell biology

Immunological databases

Structure databases

RNA sequence databases

Protein sequence databases

Nucleotide Sequence Databases

Genomics Databases (non-vertebrate)

Metabolic and Signaling Pathways

Other Molecular Biology Databases

Microarray Data and other Gene Expression Databases

NAR: Nucleic Acids Research

Organise the online database mostly on biological and bioinformatics field.

Has been identified by the Special Libraries Association (SLA) as one of the top 100 most influential journals in Biology and Medicine over the last 100 years

NAR's F1000 Articles: the Faculty of 1000 (a post-publication peer-review service that provides online evaluations of recently published research articles) provides evaluation and ratings of highly significant research articles

NAR's Featured Articles represent the top 5% of papers

in terms of

scientific excellence

significance

originality

NAR's Top Articles are updated monthly

Showed recent articles that have been most often accessed in the specified month and category

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An Open Access journal

Free for retrieval

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SOONG JIA XIN

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NG CHEE CHING

AQ100058

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AQ100041

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