EFFECT OF FREE RADICALS

lipid peroxidation of Membranes

free radical attach to double bond of mem form : Lipid peroxide

this LIPID peroxide: unstable & Reactive=
extensive damage to All membranes

Non-peroxidative mito mem damage

DNA damage

1- free radical with thymine =Oxidation

2- single strand DNA

3- Mutations or cell Killing

PTN cross linking

cystine - lysine - methionine - histidine

enzyme inactivation :Sulfa-hydral enzyme