Drugs of 5HT receptr

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Drugs of 5HT receptros

5HT 3

ondansetron

Antiemetic in chemotherapy, radiation and postoperatively

An ion channel (no 2nd messengers)

Found in area of posterma, peripheral sensory and enteric nerves

5HT 2(a-c)

Cyproheptadine

Has H1 blocking effects, so it's used for seasonal allergy

Octreotide is a better drug however

Antagonist for HT2 in carcinoid and G.I tumors

Olanzapine

Antipsychotic

5HT 2a antagonist

In periphery: Vasodilation (flushing), contraction of G.I muscles (diarrhea), contraction of bronchioles, uterine smooth muscles and platelet aggregation

Found in CNS (excitatory)

5HT 1(a-h)

Sumatriptan

Side effects: possible asthenia, throat or chest pain

Lowers migrain pain by causing vasoconstriction

Agonist at 5HT 1d in cerebral vessels

buspirone

Anxiolytic (Generalised anxiety disorder, GAD) Remember "a for anxiety"

Partial agonist at 5HT 1a receptor

Smooth muscles (excitatory or inhibitory)

CNS: Inhibitory