Immunology

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Aff Mat

After a B cell with antigen is initially activated by at Th cell

Affinity Maturation happens in germinal center - B cell is activated by Th2, starts rapidly reproducing and mutating (regulated by Th2). The one with the highest affinity reproduces - some become plasma.

1) IgM released by B cells to make immune complexes

2) Dentric cells pick up complexes and bring to follicle to allow affinity maturation of B cells

3) If B cell has high affinity to an antigen and gets costimulation by Th2 then it starts to proliferate

HUMORAL

Parasite

Allergy

Subtopic

RhIgG = Hemolytic Anemia

AB

CELLULAR IMMUNITY

Integrin

ICAM/VCAM (endothelium)

Allergy (type 4 DTH)

Poison Ivy

Immune Cells

Main topic

=

Macrophages

IL-4 (humoral)

IL-12 (cellular)

Leukocytes

LYMPHOCYTES (adaptive immunity)

NK Cells

B Cell

Immunoglobulin

A: Mucosal immunity (passive)

E: Mast Degranulation - hypersensitivity

G: Opsinization, complement, passive immunity

M: Complement activation

VDJ recomb

AID1

Rag

Basophil (Inflam)

Eosinophils (Parasites)

Monocytes/MDM (phagocytes)

Neutrophils

makes compliment (as does liver)

Inflammation

Phagocyte

Mast Cells

target of corticosteroids

Inflammatory