F-18 Bone Scintigraphy

Neoplastic diseaseOccult fractureStress reaction/stress fractureAvascular necrosisArthritisReflex sympathetic dystrophyBone infarctsBone graft viabilityPaget's diseaseUnexplained bone pain

Patient may eat and take medications as necessary before the procedure.Obtain focused history and focus on the following:A.Clinical indication for the study, including current symptoms.B.History of fractures, trauma, and associated bone abnormalities.C. History of current or previous therapeutic protocols that may affect the bone scan.D.History of surgical procedures that may affect the bone scan.E.Review of current medications that may affect the distribution of the tracer.F. Confirmation of pregnancy status and/or lactation.

Fluoride F18 ion normally accumulates in the skeleton in an even fashion, with greaterdeposition in the axial skeleton (e.g. vertebrae and pelvis) than in the appendicularskeleton and greater deposition in the bones around joints than in the shafts of longbones.

Sodium Fluoride F 18 Injection is a radioactive diagnostic agent for positron emission tomography (PET) indicated for imaging of bone to define areas of altered osteogenic activity

Pregnancy

Allergic Reactions: As with any injectable drug product,allergic reactions and anaphylaxis may occur. Emergencyresuscitation equipment and personnel should be immediatelyavailable.Cancer Risk: Sodium Fluoride F 18 Injection may increase the risk of cancer. Use the smallest dose necessary for imaging and ensure safe handling to protect the patient and health care worker.

No adverse reactions have been reported for Sodium Fluoride F 18 Injection based on a review of the published literature, publicly available reference sources, and adverse drug reaction reporting systems.

Sodium Fluoride F 18 Injection is supplied in a multiple-dose Type I glass vial with elastomeric stopper and aluminum crimp seal containing between 370 and 7,400MBq/mL (10–200 mCi/mL) of no carrier-added sodium fluoride F18, at the EOS reference time, in aqueous 0.9% sodium chloride solution. The total volume and totalradioactivity per vial are variable. Each vial is enclosed in a shielded container of appropriate thickness.

Store at 25°C (77°F) in a shielded container; excursions permitted to 15–30°C (59–86°F).Use the solution within 12 hours of the EOS reference time.

Camera Type: PET or PET/CT; StandardEnergy Peak: 511 KeV; StandardInjection to Imaging time: 90-120 minutes; StandardAttenuation correction: PET: cesium or germanium sources; PET/CT: CT acquisition.Patient Position: Supine; StandardArm position: indication specific; StandardAcquisition mode: 2-D or 3-D; StandardBed positions: Adequate to cover whole body or specific area of interest; StandardTime/Bed positions: 2-D (2-5 minutes) 3-D (2-3 minutes)View: Top of the head to the toes.