Hemostasis
Arterial
Anti-platelet
IIb/IIIa Inhibitors
Abciximab
Eptifibatide
PCI/ACS
Bleeding
IV
Rapid onset
ASA
Long-term prevention
Blocks COX
No TXA2
PO
Clopidogrel
TTP
Long-term
More efficacious than ASA
PO
Ticlopidine
TIA/Stroke
Acute
Thrombolytics
Selective
tPA
$$$
Antistreplase
Nonselective
Streptokinase
Beta-hemolytic strep
Loading dose saturates Ab
Urokinase
$$$
Antidote
Aminocaproic acid
IV
Venous
Anti-coagulants
Warfarin
PT
Antidotes
Vitamin K
Fresh frozen Plasma
Long-term
PO
Pregnancy
Subtopic
GI bleed
Hematuria
Necrotic skin ulcers
Heparin
Acute
IV
PTT
Antidote
Protamine sulfate (unfrac.)
ATIII
Immune thrombocytopenia
Synthetic heparin (Fondaparinux)
LMW (Enoxaparin)
Rivaroxaban
Factor Xa antagonist