Spectrum of Activity

Clindamycin

Gram Positive (MSSA, MSSE, MRSA(CA), Strep)

Anaerobes (oral)

NOT B. Frag

Lefamulin

Gram Positive (MSSA, MRSA, Strep)

Gram Negative

Atypicals

Metronidazole

Anaerobes (gut)

DOC B. Frag

Nitrofurantoin

Gram positive (Enterococcus)

Gram negative

Fosfomycin

Gram Negative (incl. pseudomonas)

Polymyxins

Gram Neg (only Pseudomonas)

Trimethoprim, Sulfamethoxazole

Gram Positive (MSSA, MRSA, NO STREP)

Gram Negative (variable)

Lipoglycopeptides

Vanc, Dapto, Telav, Dalba, Ortito

Gram Positive (MSSA, MRSA, Strep, Entero (except Dalba)

Listeria (Linezolid)

Gentamicin, Tobramicin, Amikacin, Plazomicin

Gram positive (ONLY synergy)

Gram Negative (incl. pseudomonas)

Fluoroquinolones

Ciprofloxacin

Gram Negative (incl. pseudomonas)

Atypical

Moxifloxacin

Gram Positive (Strep)

Gram Negative (no pseudomonas)

Anaerobes (Gut, oral)

Atypicals

Levofloxacin

Gram Positive (Strep)

Gram negative (incl. pseudomonas)

Anaerobes (oral)

Atypicals

Delafloxacin

Gram positive (MSSA,MRSA + strep)

Gram negatives (incl. pseudomonas)

Anaerobes (oral, gut)

Atypicals

Azithromycin, Clarithromycin

Gram positive (strep)

Gram negative (enteric only)

Atypical

1st Generation

Tetra, Doxy, Mino

Gram positive (MSSA, MRSA, Strep)

Gram negative (non-enteric only)

Atypicals

2nd Generation

Tige, Omada, Erava

Gram positive (MSSA, MRSA, Strep)

Gram negative (enteric)

Atypicals

Penicillins

Natural penicillins

Pen G, Pen VK

Gram Positive (Strep only)

Anaerobes (oral)

Syphilus (Trep. Pal.) DOC

Anti-staph PCN

Naf, Ox, Diclox

Gram positive (MSSA and Strep)

Aminopenicillins

Ampicillin, Amoxicillin

Gram positive (Strep)

Listeria DOC

Enterococcus DOC (if susceptible)

Anaerobes (oral)

Aminopenicllins + Betalactamase Inh.

Amp/Sulb, Amox/Clavul

Gram positive (strep, Enterococcus, Listeria)

Gram Negatives (No pseudomonas)

HIB DOC

Anaerobes (gut and oral)

Ureidopenicillins + Beta lactamase Inh.

Pip/Tazo

Gram positive (strep, Enterococcus)

Gram negatives (inc. pseudomonas)

Anaerobes (oral and gut)

Cephalosporins

1st Generation

Cephalexin (PO), Cefazolin (IV)

Gram Positive (Staph, Strep, NO Entero)

MSSA DOC

Gram Negative (PEK)

Anaerobes (oral)

2nd Generation

Cefuroxime

Gram Positive (Strep)

Gram Negative

Anaerobes (oral)

2.5 Generation

Cephamycin, Cefoxitin, Cefotetan

Gram Positive (Strep A/B)

Gram Negative

Anaerobes (oral and gut)

3rd Generation

Ceftriaxome, Cefdinir

Gram Positive (strep)

S. Pneumoniae DOC

Gram Negative

Cefdinir NO Neisseria

HACEK DOC

Anaerobes (oral) *KAHOOT SAYS NONE*

3.5 Generation

Ceftazidime (IV), Cefiderocol (IV)

Gram negative (incl. pseudomonas)

4th Generation

Cefepime

Gram Positive (strep, MSSA)

Gram Negative (incl. pseudomonas)

Anaerobes (oral)

Ceftaroline (IV)

Gram Positive (MSSA, MRSA, Strep, MRSE, NO Enterococcus)

Gram Negative (HACEK)

Anaerobes (oral)

Cephalosporin + Beta Lactamase Inh.

Ceftaz/Avi, Ceftol/Tazo

Gram Positive (Strep)

Gram negative (incl. pseudomonas)

MDR Enterobacter

Anaerobes (oral)

Carbapenems

Ertapenem

Gram Positive (strep)

Gram Negative

No acinetobacter

No pseudomonas

Anaerobes

Imipenem, Meropenem, Doripenem

Gram Positive (strep)

Gram Negative

Anaerobes

Monobactams

Aztreonam

Gram Negative (incl. pseudomonas)