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Factor Xa antagonist
LMW (Enoxaparin)
Synthetic heparin (Fondaparinux)
Immune thrombocytopenia
ATIII
Protamine sulfate (unfrac.)
PTT
Subtopic
Necrotic skin ulcers
Hematuria
GI bleed
Pregnancy
Antidotes
Fresh frozen Plasma
Vitamin K
PT
Antidote
Aminocaproic acid
Nonselective
Urokinase
Streptokinase
Beta-hemolytic strep
Loading dose saturates Ab
Selective
Antistreplase
tPA
$$$
TIA/Stroke
More efficacious than ASA
Long-term
TTP
PO
Blocks COX
No TXA2
Long-term prevention
IV
Rapid onset
Bleeding
PCI/ACS
Eptifibatide
Abciximab