STAGES OF VIRAL INFECTION INHIBITORS

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STAGES OF VIRAL INFECTION INHIBITORS

Late event Inhibitors

Protease Inhibitors

end in “-navir”

What’s all the Fos about? DAM, that SIR Nel is TAL

Lopinavir

Atazanavir

Tipranavir

Nelfinavir (Viracept)

Ritonavir (Norvir)

Ritonavir + Lopinavir = Kaletra

Indinavir (Crixivan)

Saquinavir (Fortovase; Invirase)

Mosinavir

You don’t have to remember Mosinavr because it never came to the market. We just keep it for the pneumonic.

Amprinavir (Agenerase)

Prodrug: Fosamprenavir

Darinavir

Fosamprenavir

Interferons

Interferon gamma (Actimmune)

Interferon beta

Interferon beta-1b (Betaseron)

Interferon beta-1a (Avonex, Rebif)

Interferon alpha

Interferon alfa-n3 (Alferon N)

Interferon alfa-2b (Intron A)

Interferon alfa-2b (Intron A) + PEG = PegIntron

Interferon alfa-2a (Roferon A)

Interferon alfa-2a (Roferon A) + PEG = Pegasys

Letomirvir (Prevymis)

Synthetic events Inhibitors

Non-nucleosides

Foscarnet (Phosphonoformic Acid (PFA); Foscavir)

Zinc finger inhibitors

Nitrosoviron

Nitrobenzamide

Azodicarbonamide

Integrase Strand Inhibitors (INSTIS)

Cabotegravir

Bictegravir

M10 (Emtricitabine and Tenofovir) + Bictegravir = Bictarvy

Dolutegravir

Elvitegravir

Cobicistat is often administered with INSTIs, particularly Elvitegravir.

Raltegravir

Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTI)

Doravirine

Emivirine

Etravirine (Intelence)

Rilpivirine (Edurant)

Management of AIDs

Cabotegravir + Rilpivirine (Cabenuva)

M10 (Emtricitabine + Tenofovir) + Rilpivirine = Complera

Nevirapine

Atevirdine

Delavirdine

Efavirenz (Sustiva)

Management of AIDS

M10 (Emtricitabine + Tenofovir) + Efavirenz = Atripla

Nucleosides

Pyrimidines

HIV

Nucleoside Reverse Transcriptase Inhibitors (NRTIs)

Emtricitabine (Emtriva); EmTen (Emtricitabine and tenofovir)

Abacavir; ABC; Ziagen

Stavudine; d4T; Zerit

Lamivudine; 3TC (3tiacytabine); Epivir

Zalcitabine; ddC (dideoxycytidine); Hivid

Didanosine; ddI (Dideoxyinosine); Videx

Zidovudine (AZT, Retrovir)

Post exposure prophylaxis (PEP)

Dolutegravir + Lamivudine= Dovato

Dolutegravir + Rilpivirine = Juluca

LamAba (Lamivudine and Abacavir) + Dolutegravir = Triumeq

LamAba (Lamivudine and Abacavir) = Epzicom

LaZI (Lamivudine and Zidovudine) + ABC (Abacavir) = Trizivir

LaZI (Lamivudine and Zidovudine) = Combivir

Non-HIV

Fluoroidoaracytidine (FIAC); Fiacytobine

Inhibits the enzyme APEX nuclease-1 to prevent DNA repairs

Bromovinyl deoxyuridine (Brivir); BVDU; Brivudine

NRTIs used for Hepatitis

Telbuvidine

Ara-C (arabinoside cytarabine)

Uridine Derivative

Trifluridine (Viroptic)

Idoxuridine (Toxil, Herplex)

Purine

Acyclovir (Zovirax)

Taribavirin

Ribavirin

Valganciclovir (Cyanvel)

Ganciclovir

Cymevene; PO

Cytovene; IV

Zirgan; ophthalmic ointment

Penciclovir

Valacyclovir (Valtrex)

Ara-A (arabinoside adenine)

Nucleotides

Tenofovir (Viread, Vemlidy)

Tenofovir alafenamide

Descovy

Tenofovir disoproxil fumarate

+ emtricitabine

Truvada

Cidofovir (Vistide)

Adefovir (Preveeon, Hepsera)

Antisense Oligonucleotides

Used for non-viral indications

Eteplirsen

Nusinersen

Mipomersen

Used for viral infections

Fomivirsen (Vitravene)

Afovirsen

Early Events Inhibitors

Capsid binders

Pleconaril (Picovir)

M2 Proton channel inhibitors

Rimantadine (Flumadine)

Amantadine (Symmetrel, Gocovri)

Synthetic peptide

Enfuvirtide (Fuzeon)

Post attachment inhibitor

Chemokine receptor inhibitors

Mogamulizumab (Poteligeo)

Ibalizumab (Trogarzo)

Maraviroc (Selzentry, Celsentri)

Polymerase Acidic Protein (PAP) inhibitors

Baloxavir morboxil (Xofluza)

Neuraminidase inhibitors

Laninamivir (Inavir)

Zanamivir (Relenza Diskhaler)

Peramivir (Rapivab)

Oseltamivir (Tamiflu, Ebilfumin)