Hyperlipidemia

↓intracell cholesterol = ↑LDL receptor = ↓plasma [LDL]

Cholesterol

Statin

Those with CVD should be on a statin.

Lovastatin

Others

Super-

Rosuva

Pitava

Single day dosing

Simva

Atorva

Inhibits VLDL synth.

Prava

↓LDL

↓Smooth muscle proliferation

↓TGs↓Thickening of vessels↓Clotting↓Inflammation↓Blood pressure

Anti-inflammatory

↑Bone formation (women)

Hepatotoxicity

Myopathy

Rhabdomyolysis: 10x elevated CK, urine Mb and brownMyositis: Pain + CKMyalgia: Pain - CKMyopathy: Muscle dzCombos w/ these drugs increase risks:Niacin (2%)Gemfibrozil (5%)

Pregnancy

Bile-acid exchanger

Drugs

Cholestyramine

Colestipol

Colesevelam

Pruritis a/w biliary obstruction

Side Fx

Tastes like sand

↑VLDL

Acidic Drugs

Digoxin

Warfarin

Phenobarbital

Vit. A,D,E,K

Others

Hydrocortisone

Iron

Tetracycline

Thiazides

Thyroxine

Ezetimibe

Niemann-Pick C1-like protein

Blocks cholesterol absorption @ enterocyte

Triglycerides

PPAR-alpha

↑LPL expression

↑HDL

Fibrates

Fenofibrate

NOT available in the U.S. but sold in Canada

Clofibrate

Flu-like syndrome

Arrhythmia in CAD

Interactions

Displaces warfarin

Inhibits platelet aggregation

Gemfibrozil

Rash

↑LDL receptors on membrane

N3FAs

Marine Oils

Both

Niacin

↑HDL

↓TGs

↓VLDL, LDL

Cutaneous flush, pruritis

Aspirin 30 min. prior

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Peptic ulcer

Hepatic Disease

Diabetes

Gout

Cardiac arrhythmias