Renal Failure

Causes

Pre-renal

Can lead to ATN

Iatrogenic (anti-hypertensives)

Hypovolaemia

Renal A. stenosis

Precipitated by ACEI/ARBs - start ACEI dose at night then check BP and 2 in 6 weeks + check U&Es

Intra-renal

Glomerulonephritis

Nephrotoxic drugs

chemotherapy, gentamycin, ibuprofen

Rhabdomyalysis (CK 600+)

Epileptic fits, lying on floor (fall), exercise, compartment syndrome, hyperthermia, statins

Pyelonephritis

Fever, loin pain, rigors, pregnant (ureters dilate, more vulnerable)

Streptococcal infections

Immune complex deposition in small arteries - NECROSIS

Amyloid

Protein deposition after inflammation - CONGO RED STAIN

Microvascular disease (diabetes)

Post-renal

BPH

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