Henoch-Schönlein Purpura

Unknown

May be triggered by URI, chickenpox, strep throat,
medications, food, or exposure to cold weather.

Most common form of vasculitis in children

Male > Female

Genetic predisposition may be associated
with HLA-DRB1*01 allele

Not inheritable

IgA immune mediated vasculitis of unknown etiology

Palpable purpuric skin lesions
(typically appears in crops)

Arthritis (nondestructive)

Nephropathy (hematuria, RBC casts,
proteinuria, slightly elevated CK)

GI bleeding or vomiting
(potentially intussusception)

Hematuria, proteinuria

Abdominal pain/vomiting

Joint pain or swelling
(mainly knees and ankles)

Skin rash or urticaria

Majority of cases will resolve spontaneously

Supportive care: hydration, rest, pain relief

Glucocorticoids - low dose and tapered slowly if used.
Skin lesions and kidney disease do not response to corticosteroids alone. Cyclosporine may be beneficial to add.

There is no known way to prevent HSP

General health and hygiene recommendations suggested to reduce incidence of viruses that may cause the abnormal immune response seen in HSP.