Selective Serotonin Reuptake Inhibitors (SSRIs)

Mechanism of Action

blocks the reuptake of serotonin and increases its concentration in the synaptic cleft.

blocks the reuptake of serotonin and increases its concentration in the synaptic cleft.

Therapeutic Effects:
* ease symptoms of depression
* make extra serotonin available to the brain cells

Conditions Treated:
* depression
* bulimia
* OCDs
* panic disorders

Side Effects/Adverse Effects

insomnia, sweating, pruritis, cough, dyspnea, suicidal ideation, changes in taste, tremor, agitation

Off label uses

treatment of migraine

reducing diabetic neuropathy pain

generalized anxiety disorder

Nursing Considerations

* use cautiously in adolescents and or depressed/suicidal pts, as suicidal thoughts/actions could increase
* avoid use in pts w/impaired renal or hepatic function or diabetes
* renal/liver function tests before beginning therapy
* do not use an SSRI in combination with a MAOI
* do not use an SSRI in combination with St John's wort

Med examples

citalopram (Celexa)

escitalopram (Lexapro)

fluoxetine (Prozac)

sertraline (Zoloft)

paroxetine (Paxil)

vilazodone (Viibryd)

vortioxetine (Brintellix)

Prototype Drug

fluoxetine (generic)

Prozac (trade)