Arboviruses and Othe

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NETWORKS

由Lucia Michelle Linhart Velázquez-Gaztelu

B3: Hepatitis

由R G

Hospitals In The General Community

由Theshani Vijayaratnam - Turner Fenton SS (2572)

SIDEROBLASTIC ANEMIA

由Brenda Mitchell

Arboviruses and Other Zoonotics

Arthropod

Is it an arthropod vector?

mosquito?

tick?

biting fly?

vertebrate hosts

squirrels/rodents

monkeys

pigs

birds

Replication

Cytoplasm

hemorrhagic fever

aseptic viral encephalitis

Encephalitis

EEE

WEE

VEE

SLE (St. Louis encephalitis)

WNV

California encephalitis

Powassan encephalitis (European)

Diagnostic

RT PCR

early stages of Dengue & Chikungunya;

most do not exhibit virus in blood

ELISA

Families

Togaviridae

Vectors

Mosquito

Culex: WEE

Aedes: VEE

Culisetts: EEE, salt-water marsh mosquito

Host

broad range: bird, mouse, horse, human

human: dead end

high titer horse can transmit

2 glycoproteins

important for binding, entering, replicating

Chikungunya

"bends up": musculoskeletal position due to muscle & joint pain

Other Sx: fever, headache, fatige, rash, nausea, vomiting

VEE

"Venezuelan"= Central and S. America

mainly horses

mild systemic with rare encephalitis

WEE

rural western US

more frequent and less severe than EEE

infants and children

EEE

neurological sequelae

severe with high mortalitiy in children

rural US, NE to Florida, Great Lakes, Central and South America

Flaviviridae

all Flaviviridae are Arboviruses except Hepatitis C and G

Characteristics

Pathogenesis

2' viremia

Encephalitis

Hepatitis

Dengue Shock Syndrome

Ab Block

vascular endothelium

RES: liver, spleen, lymph nodes

replication in target organs

1 glycoprotein

Diagnosis

PCR

for WNV: urine PCR in recent use

EIA

IgM

Serology

Gold Standard for West Nile: CSF (spinal tap)

Culture

CSF or blood difficult (per syllabus) but lecture: Gold Standard=CSF culture

can isolate from brain of dead bird

Epidemiology

Transmission

human-human transmission via host?

E. bola

LaCrosse

California Complex Virus

Reoviridae

Colorado Tick Fever

Other Zoonotics

Poxviridae

Filoviridae

Clinical

Marburg

Ebola

Roboviruses

Bunyaviridae