类别 全部 - edema - diuretics - hypertension

作者:Courtney Rockwood 6 年以前

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Loop Diuretics

Loop diuretics are a class of medications primarily used to treat conditions like hypertension, heart failure-related edema, and severe hypercalcemia. They work by inhibiting the chloride pump in the ascending loop of Henle, effectively reducing sodium and chloride reabsorption, leading to increased urine output.

Loop Diuretics

Loop Diuretics

Prototype Drug

Lasix (trade)
furosemide (generic)

Med examples

torsemide (Demadex)
furosemide (Lasix)
bumetanide
Ethacrynic acid (Edecrin)

Nursing Considerations

* do not use in pts' with severe renal failure * monitor serum electrolytes, glucose, and uric acid with use and hematology, liver function tests * obtain W daily, monitor UO * use cautiously in pts' with gout

Off label uses

ascites
pulmonary edema
reducing Intra ocular pressure from glaucoma

Side Effects/Adverse Effects

Dehydration, electrolyte imbalances, hypotension, ototoxicity

Mechanism of Action

Conditions Treated: * hypertension * edema associated w/heart failure * severe hypercalcemia
Therapeutic Effects: * reduces BP through vasodilation * reduces edema/pulmonary congestion * decreased workload on heart
Blocks chloride pump in ascending loop of Henle, decreasing reabsorption of Na+ and 2Cl-, causing their excretion in the urine. Reduces blood volume and cardiac workload by increasing urine output.