Purine Nucleoside Phosphorylase
Overproduction of Uric Acid
Xanthine Oxidase
Interaction with Inflammatory System
Xanthine Oxidase
under-excretion of Uric Acid

Gout

Main topic

Chronic Gout

Febuxostat

Probenecid

Allopurinol

Acute Gout

NSAIDs

Colchicine

steroids

Dietary Purines

Tissue Nucleic Acids

Endogenous Purines Synthesis

Hypoxanthine

Xanthine

Uric Acid

Elevated Uric Acid Levels

urate Crystal Formation

*Gout Risk Factors:
-Male Gender
-Age
-Obesity
-Ethnicity (Pacific Islanders)
-Polymorphisms (Genetics)
-Kidney Disease

90% of cases of gout are caused by inefficient renal excretion of urate vs. overproduction