Lipid metabolism

CCK:
➢ Acts on the gallbladder and pancreas

Secretin:
➢ Causes the pancreas to release a
solution
rich in bicarbonate that helps
neutralize
he pH of the intestinal contents

1. Monoacylglycerols

2. Fatty acids

3. glycerol

4. Phospholipids

Lipids are one of the main sources of
energy in the body

Lipids make diet palatable

Lipids supply the body with fat soluble
vitamins.

Caused by a defect in lipid
digestion or absorption.

Orlistat, an antiobesity drug

1. In stomach
a) lingual lipase
b) Gastric lipase

2. In small intestine
a) pancreatic lipase

Fate of fatty acids:
1) Oxidation by tissues to give energy.
2) May remain in adipose tissue to be re
esterified into triacylglycerol again

Fate of glycerol
1) Glucose by Gluconeogenesis.
2) Pyruvate by glycolysis.
3) Triacylglycerol by lipogenesis

After meal : stimulated by
insulin

During fasting is inhibited by
anti-insulin hormones as glucagon are
secreted and increase lipolysis.

Glucose formation by
gluconeogenesis:

Oxidation for production
of energy