principles of Pharmacology

Administration

Absorption

Transfer drugs from site of admin. to the site of circulation

Dependence

It depends on

Blood Supply

Presence of food (to dely)

Presence of other meds in the stomach

compete or carier metabolism

a drug might bind to another drug to prevent absorption

Disease state

Aqueous (Passive) Diffusion

Drugs move from high to low concentration

Water-soluable drugs penetrate the cell membrane throuh aquoues channels

Increase size of drug, decrease absorption

Lipid-soluable drugs pass through membrane

Doesn't matter (size, charge)

Lipid Diffusion

Drugs migh be weak acids or bases.

Electrostaticity of lipid drugs attract water to be water soluable

Uncharged drugs are absorped readily

Henderson Hasselbalch law

You can calculate charged and uncharged molc. at any given pH

Meaning you can calculate how much is absorbed

Weak acids in Stomach. Weak bases in intestines

Can uses ATP (Active diffusion)

Can go againts the [ ]

Saturable process

Why?

Endocytosis/Exocytosis

Effect of pH

Metabolism

Excretion

Bioavailability

Dose Response

Receptor activation

Efficacy

Toxicity