coag

thrombocytopenia

thrombocytes < 10-50k

± BMBT

macroplatelets

regenerative

- production

+ consumption

DIC

- then + PTT, PT

- fibrinogen

+ FDP

+ D dimers

schistocytes

- ATIII

hemangiosarcoma

vasculitis

+ destruction

ITP (ca)

iatrogenic heparin

ehrlichiosis

+ sequestration

splenomegaly

sepsis (LA)

thrombocytopathy

BMBT

thrombocytes > 10-50k

acquired

NSAIDs

abnormal plasma proteins

FDPs

autoimmune

phenothiazine tranquilizers

uremic plasma waste products

hereditary

vWF

thrombasthenias

thrombopathies

hereditary

hemophilia A (VIII)

PTT

von Willebrand (vWF)

BMBT

any other factor (sauf XII)

multifactorial

acquired

vit K antagonists

severe liver dz

+ FDP (not filtered out)

amyloidosis

- X lost to matrix

autoimmune dz

factors

intrinsic (XII, XI, IX, VIII)

PTT (-75%)

haemophiliacs

ACT (-95%)

extrinsic (TF -> VII)

PT (-75%)

vit K antagonism

common (X, V, II, I)

PTT

PT

ACT

acquired

endothelial injury

collagen disorders

scurvy

Cushings

hereditary

collagen disorders

Ehlers Danlos

Marfan

nephritic syndrome

- ATIII

Fe deficiency anemia

inflammation

excitement/EPI

myeloproliferation

splenectomy