Kategorier: Alle - tratamento - inflamação - sintomas

af Amanda Cruz Souza 3 år siden

126

PARKINSON

A doença de Parkinson é caracterizada por uma degeneração progressiva de neurônios, resultando em sintomas como tremor em repouso, bradicinesia e rigidez. Fatores como isquemia, estresse oxidativo, inflamação e excito-toxicidade contribuem para a morte neuronal.

PARKINSON

PARKINSON

Fisiopatologia e sintomas DP

MPTP convertida em MPP⁺
MAO

MAO-B

REGIDEZ EM REPOUSO
TREMOR EM REPOUSO
SINAIS INICIAIS: BRADICINESIA
conexões ao músculo pelo cortex motor
TREMORES
↑ ACETILCOLINA
↓ D₂

MORTE NEURONAL

The ending of a story is essential. We all know that if the ending is weak, what happened before loses its importance. So make it unpredictable, but fair. A resolved ending answers all the questions and ties up any loose threads from the plot.

ISQUEMIA
INFLAMAÇÃO
ESTRESSE OXIDADTIVO

This is the closure section of the story.
See examples of possible outcomes below:

ataque de enzimas, lipídios da membrana e DNA

Try answering these questions to come up with a closure:
- Have all the problems been solved?
- Is there a clear picture of what happens with each character in the story?
- Has the challenge transformed your main character?
- How do the characters feel in the end?

hipoxia

Try answering these questions in order for you to come up with a closure:
- Have all problems been solved?
- Is it clear what happens with all your characters in the story?
- Has the challenged transformed your main character?
- How do the characters feel in the end?

EXCITOTOCIDADE

This is the moment when the main character surpasses the last obstacle and finally faces their greatest challenge.
The climax usually follows one of these patterns:


Type in your answer.

↑ da concentração de Ca²⁺ intracelular e ↑ de glutamato

Tratamento

The middle of the story is where you add layers of complications that will lead to the end. Reveal more about the character's journey. Did their personality go through changes? How did they overcome the challenges? And as you build up the story’s central conflict, make it more personal to that character. Also, from the middle act, you have to lead into the final act.

AGONISTA DA D₂

Your character(s) need(s) motivation in order to solve the challenge(s).

CABERGOLINA

Secondary characters also might have motivs beacuse of which they may cross path with main character or which might trigger them to help the main character.

hipotensão

baixa excreção urinária

efeito dopaminérgico

↓ níveis séricos de PRL

PERGOLIDA

Secondary characters might also have motives that lead them to cross paths with the main character or which might trigger them to help the main character.

efeitos adversos

constipação

palpitação

alucinações

discinesia

tontura

Inibe a excreção de prolactina

10-100 vezes mais potente que a BROMOCRIPTINA

BROMOCRIPTINA

Why does your character need to confront this challenge? What does he/she expect to accomplish by solving it?
See a few examples:

fármaco de substituição por PRAMIPEXOL E ROPINIROL.

PRAMIPEXOL

Subtópico

ROPINIROL

sonolência e alucinações

riscos de reações fibróticas nos pulmões

sonolência

náuseas e vômitos

meia-vida de absorção é de 0,2 a 0,5 hora

Contraindicado

Gravidez

Hipertensos

Inibe a prolactina pela adeno-hipófise

LEVODOPA

Each story has a main character and that character usually needs to solve a problem or challenge. The character's challenge is the one that creates tension throughout the story.

Efeitos adversos

Efeitos psicológicos

↑ D2

Esquizofrenia-símile em 20% indivíduos

Náuseas e anorexia

Hipotensão

Flutuações no estado clínico

Regidez

Bradicinesia

Discinesia

Paciente com uso prolongado de Levodopa

Boa absorção no intestino delgado

Type in any other challenges which other characters in the story need to face.

66% excretada na urina

Pró-fármaco

ativado- DOPA

Diminuição da inibição da MAO quando é associada a um decarboxilase

A medida que a DP avança a levodopa perde sua eficácia terapêutica
FÁRMACO DOPAMINÉRGICO
Tratamento de primeira linha para a DP e é combinada com um inibidor da: dopadescarboxilase

In most stories, there are 3 challenges. The number 3 is a mystical number symbolizing completeness. Try to come up with interesting challenges with which your character needs to struggle.
See a few examples below:

BENSERAZIDA

CARBIDOPA

BEGINNING

In the beginning of the story (or the exposition), you will need to introduce the setting and characters. You might also want to introduce the main conflict. This part of the story is important because it gives the reader necessary background information and maybe even a first insight into a character’s personality.

SETTING

The setting (time & place) of a story can change throughout the plot.

Sensory detail

Sensory details include sight, sound, touch, smell, and taste. These details are important because they create depth in your setting.
See a few examples below:

Sensory details

Weather

The weather is an important element in your story because it can highly influence the ambiance and the mood of the characters.

Do these weather conditions affect the main character?

The most affected character is the main character. Write down here if he/she is affected by these weather conditions in any way. For example, if they lost a family member or their home during a hurricane, etc.

Elements of nature

Decide if you want to include an element of nature in your story. For example, a rainbow can be a very nice choice for a happy ending. The mist in a story can represent mystery and secrets. A thunder can appear in the background at the moment when the 'bad guy' of the story makes its appearance, etc.

Catastrophic event

Does your story include catastrophic weather? See a few suggestions below or add your own:
- hurricane, earthquake, storm, etc

Time

The time of the story can also change. It can describe the event of a single day or can include an entire year's plot. Anyway, don't forget to mention it.

Time of plot

Where does the story takes place?

Your story can take place wherever your imagination will take you to.
For example: in an elevator, in an enchanted forest, etc. Don't forget to give details of the environment each time the setting changes, otherwise, the story can be confusing. Also, mention the seasons as each of them has unique weather and events.

Location

CHARACTERS

Characters are essential to a good story. Usually, the protagonist(s) is/are the most affected by the plot. Introduce a character by focusing on their actions, interests, and occupation, as the physical appearance doesn't make a difference in most cases.

Character's name

Type in the name of your character.

Other

Add other qualities/attributes of the character.

Main Goal

What is your character's main goal?

fight Evilfind lovedefeat his/her enemyrule the worldmake friendstime travelmake an awesome discoveryOther

Character traits

Which traits best describe the character's personality? Choose more if necessary:

introvertedloyalkindindependentquick-thinkingadventuresomeidealisticsweet-naturedcalmrisk-takercreativewittystrictfussyweirdclumsyharshaggressivecarelessclingingcowardlycrueldeceitfulimpulsiveOther

Type of character

Choose the type of your chacter:

Protagonist (main character)Antagonist (main character's opponent)Flat (stereotypical character)Round (his/ her personality develops throughout the story)Static (doesn't evolve as a person throughout the story)Dynamic (dramatical change in personality)Confidant (the main character trusts him/ her)Foil (contrasting character who enhances the personality of another character)Other