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Buildup of Citrate inhibits PFK (stops it)
a - Ketoglutarate
Succinyl-CoA
Succinate
ATP
Fumarate
Malate
H2O
FAD into FADH2
CoA
Coenzyme A is added
NAD+ into NADH
CO2
Products
2 FADH2
6 NADH
Oxidative Phosphorylation
FADH2
Accepts 2 protons
Accepts 2 electrons
2 Steps
Chemiosmosis
Final Step of Cellular Respiration
Pumps protons from inner membrane back down the (H+) gradient which results in the making of ATP through ATP synthase.
ATP SYNTHASE
Transport Protein
As protons move down the gradient ADP is turned into ATP.
Production of ATP is called Oxidative Phosphorylation
Electron Transport Chain
Complex I
Intermembrane Space
Complex II
Coenzyme Q
Complex III
Cytochrome C
Complex IV
Oxygen
Electronegative, Drives ETC. Removes 2 electrons from Complex IV and 2 Protons from the matrix (this makes water)
FAD2
Goes through Complex's 2, 3, 4
6 Protons
1.5 ATP
NADH
Goes through Complex's 1, 3, 4
10 Protons
2.5 ATP
Delivery of Electrons by NADH and FADH2
Electron Transfer & Proton Pumping
Splitting of Oxygen to form Water
Movement of Electrons
Electrochemical Gradient
NAD+ & FAD
Inner Mitochondrial Membrane
4 CO2
Pyruvate Oxidation
Pyruvate enters Mitochondria via transport protein
Cytoplasm into Matrix
Aerobic
4 ATP
2 Pyruvate
Fermentation
Lactate
Muscle Cells
Mainly in Animals
Lactate Dehydrogenase
Pyruvate converted into lactic acid and energy
Pyruvate Decarboxylase
Alcohol
Mainly in Plants
Alcohol Dehydrogenase
Microorganisms
Occurs in Yeast
Pyruvate converted into ethanol and CO2
2 Water
2 NADH
2PG
PEP
Pyruvate
Other Carbohydrates
Protein Catabolism
amino acids through hydrolysis
can enter through different stages
Occurs in Liver
Lipid Catabolism
triglycerides into glycerol and fatty acids
enter mitochondrial matrix undergo B-oxidation to become acetyl-CoA
1 NADH 1 FADH2
1 ATP
12-C fatty acid could produce 6 Acetyl-CoA molecules
2 C acetyl group removed binds with CoA to make Acetyl-CoA
2 glycerol molecules can combine to form 2 things:
2 DHAP which then turn into G3P
Cycle is dependent on oxygen needs it to drive the ETC (EN)
Higher Concentration = faster reaction rate Will reach a point of saturation where it will be at peak production
higher temp= faster reaction rates
Buildup of ADP activated PFK
Build up of ATP inhibits PFK
F6P