por Jane Matsell hace 12 años
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(1) DNAase, enzyme that destroys the lens DNA
(1) when absent in mice, the mice are born with cataracts and the lens nuclei breakdown never occurs despite the fact that apoptosis happens normally in all other tissues/cells
other possibilities
Subtopic
(1) lens proteins are resistant to degrading enzymes
(1) braking mechanism
(1)synthesis is reduced once the organelles start to degrade
well, duh, the mitochondria and ribosomes are being destroyed
(1) lens cell produces galectin-3 while it still has its organelles
(1) galectin-3 in also involved in tissue growth, apoptosis, and differentation in other tissues
(1) enxyme 15-lipoxygenase enters cell membrane and makes holes, which allows proteases to enter and degrade the organelles
(1) tumer necrosis factor, cytokine (messenger protein), induces apoptosis
lactic acid is produced by the mitochondria during their breakdown of glucose
(1) increasing concn. of lactic acid could trigger apoptosis
(1) cells (spec. the mitochondria of the cells) sense the lack of oxygen and this triggers apoptotic factors
(1) mitochondria have been shown to initiate apoptosis in other cell types
(1)As lens grows, inner lens cells become oxygen deprived
