Heart failure with reduced ejection fraction
Natriuretic peptide system
natriuretic peptides
increase vasodilation
decrease blood pressure
decrease aldosterone
decrease heart hypertrophy
Sacubitril( inhibit enzyme neprilysin) produce inactive fragment
increase bradykinin and angiotensin ll
Renin angiotensin aldosterone system
angiotensin ll
AT2 receptor
increase vasoconstriction
increase blood pressure
increase aldosterone
increase heart hypertrophy
Valsartan( inhibit angiotensin ll)